Background Artificial intelligence (AI) will have a lasting and drastic impact on medical research and healthcare. In addition to the benefits, the associated risks are also the subject of controversial debate and there are fears of serious consequences. There is an urgent need for action, which must be underpinned by scientific information. Methods By analyzing temporal and geographic patterns, including national readiness for access to AI, we therefore identified incentives and barriers to global research under socioeconomic conditions. Results The explosive increase in annual publications started in 2017. The main players in AImed research were the USA, China, the UK, Germany, and South Korea. There was a significant correlation between the publication output on AI in medicine (AImed) and the metrics for economy and innovation. Additionally, citation patterns show the disadvantage of the Global South compared to the North American and European countries. In several weaker economies: Jordan, Pakistan, Egypt, Bangladesh, and Ethiopia, a more positive position was found in relation to the number of articles suggesting a better ranking in AImed research in the future. Conclusion The results show the need for advanced global networking to ensure all relevant aspects for equitable development and the beneficial use of AImed without promoting racial or regional inequities and to enforce this not only in the AI systems of economically strong countries but also for the participation of economically weaker countries.

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