Purpose This scoping review aims to synthesize research on artificial intelligence (AI) in predicting open-heart surgery outcomes, evaluating AI model performance, and identifying gaps in data quality, algorithmic bias, and clinical applicability to guide future advancements in personalized surgical planning and patient outcomes. Methods Conducted using the PRISMA-ScR guideline, the review involved a systematic search across PubMed, Web of Science, IEEE, and Scopus. Articles were included if they focused on open-heart surgery, utilized AI methods, and were published in English. Exclusion criteria included non-relevance to open-heart surgery, non-original research, and lack of AI techniques. Data extraction included study details, AI methods, and performance metrics. Descriptive statistics were used for analysis. Results Of the 64 included studies, 89.06% were retrospective. The most frequently employed algorithm was logistic regression (n = 41), followed by random forest in 38 studies and XGBoost in 32 studies for data analysis. Most studies focused on predicting postoperative outcomes. Mortality, acute kidney injury, and complications were the outcomes that more studies concentrated on. XGBoost, used in 32 studies, exhibited the best performance in 11 of these studies. Deep learning and hybrid models were underutilized. Major limitations included inconsistent model validation, limited prospective data, and lack of diversity in patient populations. Conclusion AI demonstrates promising predictive capabilities in open-heart surgery, particularly through machine learning models. These models can already assist surgeons in real-world practice by supporting real-time risk stratification and personalized decision-making, such as identifying high-risk patients for targeted interventions. However, methodological limitations hinder clinical translation. Future work should emphasize prospective validation, explainable AI, and equitable data representation to enhance model reliability and applicability in real-world settings.